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Dystrophic form (DBE) - the upper part of the papillary dermis, which is located deeper than the light plate, suffers.
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Intrauterine causes that can lead to gene mutations are the most commonplace - smoking, drinking alcohol, taking medications and exposure to buy viagra pills factors that have a teratogenic effect.
Forms of the disease and its symptoms.
The skin of patients does not tolerate any rough mechanical or physical impact. Otherwise, in response, rejection of the epidermis and dermis quickly occurs. First, bubbles form, after opening, erosion appears in their place. In some cases, a secondary infection may join the rash.
It also has two subtypes that differ in the mechanism of viagra pills - dominant and recessive. The latter variety is represented by several clinical forms, the most severe of which is the Allopo-Siemens subtype. Kindler syndrome (mixed epidermolysis bullosa). Currently, this classification is considered conditional, since in practice there are a lot of clinical forms, which often makes it difficult to diagnose. Experts are trying to develop a more structured and acceptable classification of sildenafil online, but so far without success.
The disease develops due to a mutation in more than ten genes that encode proteins that make up the structure of the skin.
In most cases, it is inherited, less often it is acquired when changes in genes occur spontaneously.
A child can inherit the pathology from one of the parents. And even if they do not suffer from epidermolysis bullosa, adults can be latent carriers of mutated genes.
Conventionally, all causes are divided into two groupsppy - genetic and intrauterine. The main pathogenesis is a failure in the enzyme system, as a result of which some proteins become a target for enzyme attack.
The formation of bubbles occurs as a result of the destruction of key structural proteins and disruption of communication between cells at the slightest mechanical impact.
However, the first symptoms may appear much later - there is no exact timing. This may be during the neonatal period, infancy, or early childhood. Most rarely, the disease begins in adolescence, but such cases have also been reported.
Acquired epidermolysis bullosa, as mentioned above, occurs as a result of spontaneous mutations. Therefore, most often the first signs appear already in adults.
Epidermolysis bullosa congenita may present at birth. In some cases, the skin of the child is injured even at the time of passage through the mother's birth canal.
The clinical picture is in many ways similar to the symptoms of this disease in children and depends solely on which genes have changed.